日誌
憂鬱症，怎麼治？part-III(缺鎂鋅維他命C、B6，建議善存+500毫克維他命C+豆漿。) ... ...
導讀：
樂觀的人格的秘密~~~(需要鎂鋅維它命B6、C，建議善存+多喝豆漿+多喝茶。)
告訴我們：
血清素，被稱為“信心”神經化學物質。血清素給您信心
血清素需要靠色胺酸+鎂+鈣+維它命B6+維它命C(可能也需要維它命B3)來獲得
5-羥色氨酸(5HTP)通過多巴脫羧酶進一步轉化為血清素，其使用鎂，鋅，吡哆醇-5-磷酸（P5P）
，活性形式的維生素B6和維生素C作為輔助因子。
~~~
憂鬱症，怎麼治？part-II(主要缺鎂鋅，錳也有幫助，建議善存+豆漿+茶。)
告訴我們：
幾項研究證實，憂鬱症與低於正常水平的ATP產生有關。
避免猝死Part-II-OHCA起死回生(一般人應該缺維它命B群，也需要鎂鈣，也可靠吊點滴補充)
告訴我們：
要產生ATP除了靠鎂鈣，也需要維它命B群。
~~~
自殺是怎麼回事？(主要缺鎂鋅，建議善存或草莓亞培安素或桂格特級完膳+多喝豆漿。)
The serotonin (5-HT, 5-hydroxytryptamine) system has been implicated in the
pathogenesis of major depressive disorder (MDD).
血清素（5-HT，5-羥基色胺）系統與主要憂鬱症（MDD）的發病機制有關。
All antidepressant strategies have been shown to enhance 5-HT transmission
in the brain of laboratory animals.
已顯示所有抗憂鬱策略均可增強實驗動物大腦中的5-HT傳遞。
~~~
Reduced whole blood serotonin in major depression.
嚴重憂鬱症患者全血血清素減少。
Profile of Mood States (POMS)
情緒狀態簡介（POMS）
Plasma vitamin C concentration was inversely correlated with total mood disturbance
as assessed by POMS (r = −0.181, p < 0.05).
通過POMS評估，血漿維生素C濃度與總情緒紊亂呈負相關（r = -0.181，p <0.05）。
Examination of the individual POMS subscales also showed inverse associations of
vitamin C status with depression, confusion, and anger.
單個POMS分量表的檢查還顯示維生素C狀態與憂鬱，困惑和憤怒呈反比關係。
~~~
Patients with vitamin C biochemical depletion had significantly increased
symptoms of depression compared with those with higher concentrations at
baseline (p=0.035) and at 6 weeks (p=0.028).
與維生素C濃度較高的患者相比，維生素C耗竭的患者的憂鬱症狀明顯增加。
The literature most strongly supports a role for zinc deficiency in increasing
the risk of depression
文獻最有力地支持了鋅缺乏症增加憂鬱症風險
~~~
At least five studies have shown that zinc levels are lower in those with clinical
depression.[54]
至少有五項研究表明，臨床憂鬱症患者的鋅水平較低。
This mood improvement was particularly associated with improved vitamin B2 and B6 status.
情緒改善尤其與維生素B2和B6狀況改善有關。
Serotonin 1A receptor (5-HT1AR) function appears decreased in primary major
depressive disorder (MDD)
血清素1A受體（5-HT1AR）的功能在原發性重度憂鬱症（MDD）中出現下降
binding potential (BP)
結合電位（BP）
mesiotemporal cortex (MTC)
顳腦中葉皮質（MTC）
Mean 5-HT1AR BP was reduced 26% in MTC (p<0.005) and 43% in raphe (p<0.001)
in depressives versus controls.
與對照組相比，憂鬱症患者的平均5-HT1AR BP在MTC中降低了26％（p <0.005）
~~~
Binding studies have shown that divalent cations increase the affinity of
5-hydroxytryptamine 1A (5-HT1A) receptors for ligands.
結合研究表明，二價陽離子可提高5-羥基色胺1A（5-HT1A）受體對配體的親和力。
This report demonstrates a functional role for Mg2+ in the operation of
the 5-HT1A receptor located on Purkinje cells.
該報告證明了Mg2+(鎂離子)在位於Purkinje細胞上的5-HT1A受體的運作中的功能性作用。
~~~
Moreover, the in vivo studies indicate that Zn can modulate both presynaptic
and postsynaptic 5-HT1ARs
體內研究表明鋅可以調節突觸前和突觸後5-HT1ARs。
However, chronic zinc treatment induced increases in both 5-HT1AR protein levels
and density of 5-HT1A receptor binding sites in the Hp of rats.
然而，慢性鋅治療誘導大鼠Hp中5-HT1AR蛋白水平和5-HT1A受體結合位點密度增加。
總結以上：
憂鬱症患者缺少血清素，缺少鎂鋅維他命C、B6，建議一天一粒男性/女性善存+500毫克維他命C+一天喝800ml豆漿(https://yingyang.911cha.com/dWE=.html)。
全部作者的其他最新日誌
發表評論評論 (1 個評論)
- 回復 thelord2009
- 維他命C對憂鬱症有幫助的證據
憂鬱症，怎麼治？part-II(主要缺鎂鋅，錳也有幫助，建議善存+豆漿+茶。)
http://www.eyny.com/blog-5788411-770962.html
告訴我們：
重症憂鬱症患者外周血中Na+/K+ ATPaseα1（ATP1A1）基因表達降低
與ATP1A1相關的疾病包括低鎂血症
幾項研究證實，憂鬱症與低於正常水平的ATP產生有關。
The aim of this study was to evaluate the relationship between membrane fluidity and fatty acid composition and (Na,K)-ATPase activity in erythrocytes of essential hypertensive patients supplemented with antioxidant vitamins C and E.
評估補充抗氧化劑維生素C和E的原發性高血壓患者的（Na，K）-ATPase活性
A double-blind, randomized, placebo-controlled study was conducted in 120 men with essential hypertension assigned to receive vitamin C (1 g/day) +E (400 IU/day) or placebo for 8 weeks.
在120名患有原發性高血壓的男性中進行了一項雙盲，隨機，安慰劑對照研究，他們被分配接受維生素C（1 g /天）+ E（400 IU /天）或安慰劑治療8週。
Supplemented hypertensive patients showed higher activity of (Na,K)-ATPase and proportion of PUFA, and lower blood pressure, OS markers and proportion of SAFA, versus placebo.
與安慰劑相比，補充維生素C和E高血壓患者表現出較高的（Na，K）-ATPase活性。
節錄自https://www.ncbi.nlm.nih.gov/pubmed/23659494
